is classified therapeutically as a depigmenting agent. Tretinoin is
classified therapeutically as a keratolytic. Floucinolone Acetonide is
classified therapeutically as an anti-inflammatory.
of the components in Refaquin cream, hydroquinone, is a depigmenting
agent, and may interrupt one or more steps in the tyrosine-tyrosinase
pathway of melanin synthesis. However, the mechanism of action of the
active ingredients in Refaquin cream in the treatment of melasma is
cream is indicated for the short-term treatment of moderate to severe
melasma of the face, in the presence of measures of sun avoidance,
including the use of sunscreens.
cream, a combination cream product containing corticosteroid, retinoid,
and bleaching agent, is not indicated for the maintenance treatment of
melasma. The safety and efficacy of Refaquin cream in the treatment of
hyperpigmentation conditions other than melasma of the face have not